the therapeutic effect of crocin on scopolamine induced retrograde amnesia in male rats
نویسندگان
چکیده
background: the cholinergic system plays an important role in learning and memory. administration of crocus sativus (saffron) or its constituent, crocin, facilitates the formation of memory. based on above findings, in the current study the effect of crocin in antagonizing retrograde amnesia induced by scopolamine, a cholinergic receptor antagonist, in rats was investigated by using shuttle box apparatus. methods: male wistar rats (200 – 250 g) were tested for measuring their learning behavior in a step-through type passive avoidance task. all animals were trained by using a 1 m foot shock. the drugs were injected after the successful training. animals were tested 24h after training to measure step-through latency (stl). results: post-training injection of scopolamine (1 mg/kg) impaired memory performance on the test day. moreover, administration of crocin (1, 5 or 10 mg/kg) 30 min after scopolamine improved scopolamine retrograde amnesia in a dose dependent manner. on the other hand, post-training injection of crocin (1, 5 or 10 mg/kg) had no any significant effect on passive avoidance memory by itself. conclusion: considering the therapeutic effect of post-training injection of crocin on scopolamine retrograde amnesia, it may be concluded that crocin has an interaction with cholinergic system in formation of passive avoidance memory in male rats.
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولthe therapeutic effect of crocin on ketamine-induced retrograde amnesia in rats
introduction: the glutamatergic system plays an important role in learning and memory. administration of crocus sativus (saffron) or its constituent, crocin, facilitates the formation of memory. this research investigated the effect of crocin on antagonizing retrograde amnesia induced by ketamine, a glutamatergic receptor antagonist, in rats by shuttle box. methods: male wistar rats were teste...
متن کاملEffect of cerebral administration of enalapril on spatial memory in scopolamine-induced amnesia in rats
Numerous studies conducted in laboratory animals and humans indicate that angiotensin converting enzyme inhibitors reinforce memory and learning. In this paper we study the effect of injection of enalapril into the cerebral ventricles on spatial memory of white mice in the double- y maze, following the induction of an Alzheimer- like amnestic model with scopolamine. To estimate the duration o...
متن کاملThe effect of Crocin on scopolamine induced spatial learning and memory deficits in rats
Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagoni...
متن کاملThe effect of intracerebroventricular administration of insulin on memory impairment-induced by scopolamine in male rats
Introduction: Cholinergic neuronal deficiency is one of the main causes of Alzheimer's pathology, which leads to learning and memory impairment. Scopolamine is a muscarinic cholinergic antagonist commonly used to induce Alzheimer's disease (AD). Insulin also regulates learning and memory function. Thus, the aim of this study was to determine the effect of central administration of insulin on pa...
متن کاملThe effect of Crocin on scopolamine induced spatial learning and memory deficits in rats
Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagonist,...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
مجله دانشگاه علوم پزشکی کرمانشاهجلد ۱۶، شماره ۲، صفحات ۹۲-۹۹
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023